scoper - The SCOPer package
Provides a computational framework for unsupervised identification B cell clones from adaptive immune receptor repertoire sequencing (AIRR-Seq) datasets. This method is based on spectral clustering of the junction sequences of B cell receptors (BCRs, Immunoglobulins) that share the same V gene, J gene and junction length.
Spectral Clustering for clOne Partitioning (SCOPer)¶
- defineClonesScoper: Clustering sequences into clonal groups.
- analyzeClones: Summary statistics and visualization of the clonal clustering results.
- Nouri N and Kleinstein SH (2018). A spectral clustering-based method for identifying clones from high-throughput B cell repertoire sequencing data. Bioinformatics, 34(13):i341-i349.